Ulrich SCHWEIZER (Bonn, Germany)
Ulrich Schweizer studied biochemistry in Bayreuth, Germany, until 1998 and received his PhD in neurobiology from the University of Würzburg, Germany in 2002. He spent one year in the Stroke Branch, National Institutes of Neurological Disorders and Stroke, at the NIH, Bethesda, Maryland. He joined the Institute of Experimental Endocrinology at the Charité-Universitätsmedizin Berlin, Germany, and founded an independent junior group “Neuro¬biology of Selenium” in the Neuroscience Research Center. In 2010 he received his habilitation for biochemistry from the Charité und moved in 2013 to University of Bonn as professor of biochemistry at the medical faculty.
His current research interests are:
– Functions of selenoproteins within the brain
– Biosynthesis of selenoproteins
– Catalytic mechanism of deiodinases
– Thyroid hormone transporter MCT8
– tRNA modification (isopentenylation) and fidelity of translation (ribosomal profiling)
Research in the Schweizer lab spans a wide spectrum of methods from biochemistry to animal experiments.
Dr. Schweizer published close to 100 papers in peer-reviewed journals, several chapters in monographies, and four chapters in a major German biochemistry textbook. Together with three other colleagues he edited the 4th edition of Selenium: Its Molecular Biology and Role in Human Health, Springer, 2016.
Dr. Schweizer served on the board of the German Society for Endocrinology and organized its 61st Annual Meeting in Bonn in 2018.
1) Zhao W, Bohleber S, Schmidt H, Seeher S, Howard MT, Braun D, Arndt S, Reuter U, Wende H, Birchmeier C, Fradejas-Villar N, Schweizer U.2019 “Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.” J Biol Chem. doi: 10.1074/jbc.RA119.009369
2) Schweizer U, Fradejas-Villar N. 2016 “Why21? The significance of selenoproteins for human health revealed by inborn errors of metabolism” FASEBJ. 30,3669-3681.
3) Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, PortoFreitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ ,Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M. 2018 “Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis” Cell 172,409-422
4) Mondal S, Raja K, Schweizer U, Mugesh G. 2016 “Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones” Angew. Chem. Int. Ed. 55,7606-30.(Review)