DISSECTING NOREPINEPHRINERGIC SIGNALING PATHWAYS IN HYPOTHALAMUS
Dedicated brain circuits drive innate motivated behaviours such as feeding and drinking. Our focus is to dissect out the neural circuits that control feeding behaviour in terms of underlying cell types, their connectivity and activity. We use genetic approaches to define neuronal populations and remotely manipulate their electrical activity with optical / pharmacological tools while measuring their contribution to feeding. Ultimately understanding these circuits will help us to gain insight into how neural populations give rise to behaviour and may also explain some of the diseases associated with their dysregulation such as obesity.