ORAI CALCIUM CHANNELS IN HEALTH AND DISEASE

Mohamed TREBAK

(Hershey, PA, USA)

ORAI CALCIUM CHANNELS IN HEALTH AND DISEASE

09:45 AM 18 April / Nisan 2020

Abstract

ORAI (ORAI1, ORAI2, and ORAI3) proteins form a family of highly Ca2+-selective channels at the plasma membrane. ORAIs are activated by stromal-interacting molecules (STIM1 and STIM2), which are Ca2+ sensing proteins located in the endoplasmic reticulum. STIM and ORAI proteins are ubiquitously expressed in all mammalian tissues and form store-operated Ca2+ entry (SOCE) channels. Mutations or altered expression of STIM and ORAI proteins are associated to a number of diseases, including cardiovascular and airway diseases and cancer. Here we will discuss our current understanding of ORAI channel signaling and regulation and their contribution to several pathologies.

taksim perdeci kadikoy perdeci sisli perdeci